Sit on the Left side of the plane for the best views on flights from Baltimore to St. Louis. While takeoff offers good water views on the right, the landing approach into St. Louis provides the most distinctive and recognizable landmark—the Gateway Arch—which is genuinely impressive from the left side during final approach. The Mississippi River views on descent outweigh the Chesapeake Bay views on departure.

During takeoff from Baltimore Washington International (BWI), sit on the Right side for the best views. BWI typically departs to the northeast on Runway 10L/10R or southwest on Runway 28L/28R. Right-side seats on a northeast departure capture the Patapsco River estuary and Chesapeake Bay immediately after climb-out, with Baltimore's Inner Harbor visible below. On southwest departures, right seats offer views of the Patuxent River valley and northern Maryland farmland. Notable sights include: Patapsco River estuary, Chesapeake Bay (northeast departures), Baltimore Inner Harbor, Patuxent River valley.

When landing at Lambert St Louis International (STL), sit on the Left side for the best views. Approaching STL typically uses Runway 12L/12R or 30L/30R. Left-side seats on a northeasterly approach (Runway 12) provide excellent views of the Mississippi River as it curves through St. Louis, the Gateway Arch on the riverfront, and the downtown skyline. On southwesterly approaches (Runway 30), left seats show the Meramec River confluence and southern Illinois bluffs. Notable sights include: Mississippi River, Gateway Arch, St. Louis downtown skyline, Meramec River confluence.

The flight from Baltimore Washington International (BWI) to Lambert St Louis International (STL) takes Approximately 2 hours 15 minutes.

The flight path crosses the Appalachian foothills of West Virginia and eastern Kentucky, passing west of the Blue Ridge Mountains. The Ohio River valley becomes visible around the midpoint, with the river snaking through forested terrain. As the aircraft approaches St. Louis, the landscape flattens into the Mississippi River lowlands and Illinois prairie. No major mountain ranges are directly on the route, but the Appalachian ridges appear as distant, hazy terrain to the southeast during the first hour of flight.