Sit on the Left side of the plane for the best views on flights from Cancun to Charlotte. The left side wins overall due to the spectacular Cancun departure views over the Hotel Zone, Nichupte Lagoon, and Caribbean coastline, which are among the most visually striking airport departures in the Americas. The landing views on the right are solid but relatively ordinary suburban Piedmont scenery. The left side also tracks the Gulf of Mexico coastline through parts of the cruise, offering glimpses of the Gulf waters and eventually the Gulf Coast of the US.

During takeoff from Cancun International (CUN), sit on the Left side for the best views. Cancun's primary departure runway 12/30 typically sees northbound departures heading northwest, putting the left (west/south) side over the Hotel Zone barrier island, Nichupte Lagoon, and the Caribbean coastline. The left side gets a clear look at the turquoise shallow waters of the lagoon contrasting with the deep blue Caribbean before the aircraft turns north over the Yucatan. Notable sights include: Nichupte Lagoon (vivid turquoise enclosed water), Cancun Hotel Zone barrier island strip, Caribbean Sea coastline, Isla Mujeres visible offshore to the northeast.

When landing at Charlotte Douglas International (CLT), sit on the Right side for the best views. Charlotte Douglas typically uses runways 18C/36C or 18L/36R oriented north-south, with arrivals commonly from the south or southwest. A right-side seat on approach from the south gives views over the Charlotte skyline as the aircraft descends from the southwest, with the Catawba River and Lake Norman visible to the north. The left side faces away from the city center on this approach. Notable sights include: Charlotte city skyline (Uptown Charlotte towers), Lake Norman to the north, Catawba River corridor, suburban sprawl of Mecklenburg County.

The flight from Cancun International (CUN) to Charlotte Douglas International (CLT) takes Approximately 3 hours 15 minutes to 3 hours 45 minutes.

The flight tracks northwest over the Yucatan Peninsula briefly, then crosses the Gulf of Mexico for a long overwater segment. The Mississippi Delta and Louisiana coastline may be visible depending on routing, followed by the flat Gulf Coastal Plain of Mississippi and Alabama, then the low hills of the Tennessee Valley region and finally the rolling Piedmont of Georgia and the Carolinas approaching Charlotte.