Sit on the Left side of the plane for the best views on flights from Santo Domingo to Frankfurt. Left side wins at both ends of the flight. During the transatlantic cruise at 35,000 feet there is little to distinguish sides over open ocean, but the left seat delivers the best views at both departure over Santo Domingo's coast and arrival over Frankfurt's skyline and the Main River.

During takeoff from Herrera International (HEX), sit on the Left side for the best views. HEX (Herrera) sits just west of central Santo Domingo. Departures typically head east or northeast over the city. A left/north-facing seat gives you the Caribbean coastline along the southern shore of Hispaniola, the dense urban grid of Santo Domingo, and the Ozama River mouth. Right side faces inland toward suburban sprawl with less visual interest. Notable sights include: Caribbean Sea coastline south of Santo Domingo, Ozama River delta, Colonial Zone urban grid near the waterfront, Cordillera Central foothills to the north.

When landing at Frankfurt Main (FRA), sit on the Left side for the best views. Frankfurt airport typically uses runways 25L/25R for westerly landings, approaching from the east over the Rhine-Main region. Left side seats face south, giving views over the Frankfurt city skyline, the Main River, and the Taunus hills. Right side faces north toward flat agricultural land with far less character. Notable sights include: Frankfurt city skyline (Bankenviertel high-rises), Main River bends west of the city, Taunus hill range to the northwest, Rhine River visible to the west near Mainz.

The flight from Herrera International (HEX) to Frankfurt Main (FRA) takes Approximately 9 to 10 hours.

After departing Hispaniola the route tracks northeast over the Atlantic, passing north of the Azores archipelago (occasionally visible as small dark volcanic islands on clear days at distance), then crossing into European airspace over Portugal or northern Spain, tracking across France with the Pyrenees visible to the south on clear days, before descending into the Rhine-Main basin over central Germany.