Sit on the Left side of the plane for the best views on flights from New York to Guayaquil. The left side delivers the iconic New York departure view including the full Manhattan skyline, and during the cruise over the Caribbean and Colombia, the left side also offers better angles on the Colombian coast and Andean cordillera as the route tracks south-southwest. The right side landing at GYE is good but shorter in duration than the extended takeoff spectacle.

During takeoff from John F Kennedy International (JFK), sit on the Left side for the best views. JFK departures on runway 31L/31R head northwest, putting Manhattan and the full New York skyline on the left side. You get a clear view of the East River, Brooklyn, and the Manhattan skyline as the aircraft climbs out over Jamaica Bay and turns south. Notable sights include: Manhattan skyline, East River bridges (Brooklyn and Manhattan Bridge), Jamaica Bay wetlands, Verrazano-Narrows Bridge.

When landing at Simon Bolivar International (GYE), sit on the Right side for the best views. GYE's runway 03 approach comes in from the south over the Gulf of Guayaquil, putting the city of Guayaquil and the Guayas River estuary on the right side. The Andes foothills are also visible to the right on final approach. Notable sights include: Gulf of Guayaquil, Guayas River estuary, Guayaquil city waterfront (Malecón 2000), Andes foothills to the east.

The flight from John F Kennedy International (JFK) to Simon Bolivar International (GYE) takes Approximately 6 hours 30 minutes to 7 hours.

The route tracks south over the western Atlantic, crossing Cuba or Hispaniola depending on routing, then over the Caribbean Sea, the Colombian coast near Cartagena or Barranquilla, and the northern Andes of Colombia before descending into Ecuador. The Magdalena River valley in Colombia and the green Andean ridgelines are visible on clear days. The Gulf of Guayaquil and the broad Guayas River delta are prominent on descent.