Sit on the Right side of the plane for the best views on flights from New York to St. Louis. Right-side seats offer superior views at both ends: the East River and Manhattan during departure, and the Mississippi River and Gateway Arch during approach. The westbound flight path generally keeps the river systems and major landmarks on the right side of the aircraft.

During takeoff from La Guardia (LGA), sit on the Right side for the best views. LGA typically departs eastbound (Runways 04/22, with eastbound preference on 04). Right-side seats capture the East River, Manhattan's east side, and the initial climb over Queens and Long Island Sound before heading inland toward St. Louis. Notable sights include: East River (immediate foreground), Manhattan skyline (left-center distance), Long Island Sound (right horizon), Queens residential grid (foreground-right).

When landing at Lambert St Louis International (STL), sit on the Left side for the best views. STL typically lands westbound (Runways 12L/30R, with westbound preference on 12). Left-side seats provide views of the Mississippi River, downtown St. Louis, and the Gateway Arch during descent and final approach from the east. Notable sights include: Mississippi River (dominant feature), Gateway Arch (downtown St. Louis), downtown St. Louis skyline, Illinois bluffs (east bank).

The flight from La Guardia (LGA) to Lambert St Louis International (STL) takes Approximately 4 hours 15 minutes.

The flight path crosses the Appalachian foothills (Pennsylvania/West Virginia border), visible as rolling terrain with ridge lines running northeast-southwest. The Ohio River valley appears around the 2-hour mark, flowing northwest. As the aircraft descends into Missouri, the terrain flattens significantly into the Mississippi River valley, with agricultural fields and scattered towns dominating the landscape.