Sit on the Left side of the plane for the best views on flights from Newark to Indianapolis. The left side wins overall due to the spectacular Manhattan and New York Harbor views on departure, which are among the most iconic urban aerial views in the world. The landing views on the right are interesting but Indianapolis is a modest skyline. Left side passengers also get views of the Pennsylvania farmland patchwork and Ohio's flat agricultural grid during cruise.

During takeoff from Newark Liberty International (EWR), sit on the Left side for the best views. EWR typically departs westbound on runway 22L/22R or northbound on 04L/04R. On a westbound departure toward IND, the left side gives you the Manhattan skyline and Upper New York Bay as the aircraft climbs and turns west. The Hudson River, Statue of Liberty, and the full sweep of Lower Manhattan are clearly visible on the left during climb-out. Notable sights include: Manhattan skyline, Hudson River, Upper New York Bay, Statue of Liberty.

When landing at Indianapolis International (IND), sit on the Right side for the best views. Indianapolis International typically lands on runway 23L/23R from the northeast, meaning the aircraft approaches from the northeast heading southwest. The right side gives a clear view of downtown Indianapolis — the distinctive circular Monument Circle, Lucas Oil Stadium, and the White River — as the plane descends over the eastern suburbs. Notable sights include: Downtown Indianapolis skyline, Monument Circle, Lucas Oil Stadium, White River.

The flight from Newark Liberty International (EWR) to Indianapolis International (IND) takes Approximately 1 hour 45 minutes to 2 hours.

The flight crosses the Allegheny Plateau in western Pennsylvania, where the folded ridges of the Ridge-and-Valley Appalachians give way to the flatter Allegheny Plateau. Over Ohio the terrain becomes almost entirely flat agricultural land — large rectangular field patterns in tan and green are visible from cruise altitude. The flight crosses the Ohio River valley near the Ohio-Indiana border, where the river appears as a dark winding line through the flat landscape. Indiana is uniformly flat glaciated farmland with a dense township-and-range grid of roads visible from 30,000 feet.