Sit on the Left side of the plane for the best views on flights from Frankfurt to Bilbao. The left side wins overall because the flight tracks southwest across France, keeping the Pyrenees on the left side as the aircraft descends toward northern Spain. The left seat also catches the Rhine valley on departure. The right side has the Bay of Biscay on approach but misses the Pyrenees entirely.

During takeoff from Frankfurt Main (FRA), sit on the Left side for the best views. Frankfurt typically departs westbound on runway 25C/25R, meaning the left side faces south. As the aircraft climbs and turns southwest toward Spain, the left side picks up the Rhine valley and the Taunus hills. The right side faces north over flat Hessian farmland with little of interest. Notable sights include: Rhine River valley, Taunus hills, Frankfurt city skyline receding behind, Main River confluence.

When landing at Bilbao (BIO), sit on the Right side for the best views. Bilbao airport sits in a narrow valley and typically lands on runway 30, approaching from the southeast over the Basque hills. The right side faces northwest toward the Cantabrian coast and the Bay of Biscay, giving a clear view of the coastline and the city of Bilbao in the estuary below. The left side looks inland over forested ridges. Notable sights include: Bay of Biscay coastline, Bilbao estuary (Ría del Nervión), Cantabrian mountain ridges, Basque coastal cliffs.

The flight from Frankfurt Main (FRA) to Bilbao (BIO) takes Approximately 2 hours 10 minutes.

The route crosses the Vosges hills in Alsace, then tracks over the Massif Central plateau of south-central France, passing west of Clermont-Ferrand. As the aircraft descends toward Bilbao, the western Pyrenees are visible to the left, with peaks reaching 6,000-8,000 feet. The Landes forest of southwest France — one of Europe's largest man-made pine forests — appears as a vast dark-green carpet below during the descent phase.