Sit on the Left side of the plane for the best views on flights from Frankfurt to Florence. Left side wins at both ends of the flight. Over the Atlantic the views are largely ocean regardless of side, but the left side also tracks closer to the southern English coast and the Azores region during the transatlantic crossing, and picks up the Carolina coastline on descent.

During takeoff from Frankfurt Main (FRA), sit on the Left side for the best views. Frankfurt departures on runway 25L/25C head westward, and the left side gives you a clear view south over the Rhine-Main plain, the city of Frankfurt's skyline, and the Taunus hills to the northwest. The right side faces north toward flat agricultural land with little of interest. Notable sights include: Frankfurt city skyline (Bankenviertel towers), Main River bends, Taunus hills to the northwest, Rhine valley in the distance.

When landing at Florence Rgnl (FLO), sit on the Left side for the best views. Florence Regional Airport (FLO) in South Carolina typically uses runway 27 for westward landings, meaning the approach comes from the east. The left side on approach faces south, giving views over the flat South Carolina coastal plain, pine forests, and the Pee Dee River system. The right side faces north over similar flat terrain with less geographic interest. Notable sights include: Pee Dee River and its tributaries, flat South Carolina coastal plain pine forests, Florence city grid below on final approach.

The flight from Frankfurt Main (FRA) to Florence Rgnl (FLO) takes Approximately 9 to 10 hours.

The route crosses the English Channel near the Thames Estuary, then tracks southwest over Cornwall and out into the North Atlantic. The flight passes well north of the Azores archipelago. The mid-Atlantic is open ocean with occasional cloud systems. Approaching North America, the route crosses the Canadian Maritimes near Nova Scotia or Newfoundland, then tracks south along the US East Coast over the Carolinas before descending into Florence.