Sit on the Left side of the plane for the best views on flights from Frankfurt to Prague. Left side wins both takeoff and landing on this route. During the cruise portion heading roughly east-northeast, the left side also faces north toward the Ore Mountains (Erzgebirge) ridge marking the German-Czech border, which is the most topographically dramatic feature of the entire flight path.

During takeoff from Frankfurt Main (FRA), sit on the Left side for the best views. Frankfurt departures heading east typically use runway 07R/07L, climbing out over the city. The left side gives you a clear view south over the Main River valley, the Taunus hills to the northwest, and the Frankfurt skyline receding behind you. Right side faces north toward flat Rhine-Main plain with less visual interest. Notable sights include: Frankfurt city skyline and Main River bend, Taunus hills to the northwest, Rhine River valley to the west, Sachsenhausen district rooftops.

When landing at Ruzyne (PRG), sit on the Left side for the best views. Prague Ruzyne typically receives eastbound traffic from the west on runway 06, meaning the aircraft approaches from the west-southwest. The left side faces south, giving views over the Vltava River winding through central Prague, Prague Castle on its hill, and the historic city center. Right side faces north toward suburban sprawl. Notable sights include: Vltava River and its meanders through central Prague, Prague Castle and Hradcany hill, Old Town and Charles Bridge area, Bohemian uplands to the south.

The flight from Frankfurt Main (FRA) to Ruzyne (PRG) takes Approximately 55-65 minutes.

The flight crosses the Bohemian Forest (Bohmerwald) foothills in western Bohemia, then the Ore Mountains (Erzgebirge) range along the German-Czech border visible to the north, followed by the rolling Bohemian plateau and agricultural lowlands leading into Prague. The route passes near Pilsen (Plzen) roughly 50km south of the flight path.