Sit on the Right side of the plane for the best views on flights from Sao Paulo to Houston. The right side offers the better overall experience. While left is superior at takeoff over São Paulo, the right side captures the Amazon basin river systems and the Gulf of Mexico coastline approach, plus the dramatic Houston Ship Channel industrial landscape on arrival. The left side is largely over open ocean and featureless terrain for most of the cruise.

During takeoff from Guarulhos (GRU), sit on the Left side for the best views. GRU departures heading northwest on runway 09R/27L or northbound on 10/28 typically swing left over the Serra da Cantareira range and give a clear view back over metropolitan São Paulo. The left side catches the dense urban sprawl of São Paulo city center and the Tietê River valley as the aircraft climbs out westward. Notable sights include: Serra da Cantareira hills to the north, Tietê River snaking through the urban grid, São Paulo city center skyline to the southwest, Guarulhos urban area directly below.

When landing at George Bush Intcntl Houston (IAH), sit on the Right side for the best views. IAH arrivals from the south typically approach on runways 26L/R or 15R heading northwest or southeast, and the right side picks up the Houston Ship Channel, the industrial complex of the East End, and the downtown Houston skyline as the aircraft descends over the flat Gulf Coastal Plain. Lake Houston is also visible to the right on final approach from the southeast. Notable sights include: Houston Ship Channel and refinery complex, downtown Houston skyline, Lake Houston to the northeast, flat Gulf Coastal Plain grid of suburban development.

The flight from Guarulhos (GRU) to George Bush Intcntl Houston (IAH) takes Approximately 9 to 10 hours.

The route tracks northwest across the Brazilian interior over the Cerrado savanna of Mato Grosso and Goiás states, then crosses the Amazon basin where the right side may show large river tributaries including the Araguaia or Tocantins rivers depending on exact routing. The flight then crosses Venezuela and the southern Caribbean, passing over or near the Yucatán Peninsula and the Gulf of Mexico before descending into Houston. The Gulf of Mexico crossing offers open water views on both sides for roughly 90 minutes before landfall on the Texas coast.