Sit on the Right side of the plane for the best views on flights from Sao Paulo to Miami. The right side wins overall. The São Paulo departure view is more dramatic with the city and Atlantic Forest escarpment, and during the flight the right side faces generally east and southeast, giving views of the Caribbean island chains as the flight crosses the Lesser and Greater Antilles. The left side landing into MIA is excellent, but the cumulative right-side experience across the full flight edges it out.

During takeoff from Guarulhos (GRU), sit on the Right side for the best views. GRU typically departs on runways 09R/27L or 09L/27R. Northbound departures toward MIA often involve a left turn after takeoff heading roughly northeast, putting the Serra da Cantareira and greater São Paulo metro on the right side. The right side gets the sprawling São Paulo urban grid and the green ridgelines of the Atlantic Forest escarpment. Notable sights include: Serra da Cantareira hills to the north, São Paulo city center skyline to the southwest, Tietê River valley cutting through the urban fabric, Guarulhos industrial zones and reservoirs near the airport.

When landing at Miami International (MIA), sit on the Left side for the best views. MIA typically uses runways 08L/26R and 09/27. Arrivals from the south and southeast commonly approach over Biscayne Bay and the Miami Beach barrier island. The left side on approach from the south gives you the Miami Beach coastline, Biscayne Bay, and the downtown Miami skyline before touchdown. Notable sights include: Miami Beach barrier island and Atlantic Ocean surf line, Biscayne Bay with its turquoise shallow water, Downtown Miami and Brickell skyline, Port of Miami with cruise ships at the causeways.

The flight from Guarulhos (GRU) to Miami International (MIA) takes Approximately 8 to 9 hours.

After departing Brazil the flight crosses the Amazon basin lowlands of northern Brazil, then the mouth of the Amazon River near Belém — a massive brown sediment plume visible from altitude. The route then crosses the Caribbean Sea, passing near or over the Lesser Antilles island chain including Barbados and the Windward Islands, then the Greater Antilles including Hispaniola and Cuba, before crossing the Florida Straits into Miami. The turquoise shallow-water banks of the Bahamas are often visible on descent.