Sit on the Right side of the plane for the best views on flights from Orlando to Los Angeles. Right side wins at both ends of the flight. During cruise at 35,000 feet heading west-northwest, the right (north) side also gives better views of the Gulf Coast briefly after departure, then the Texas Hill Country and Guadalupe Mountains, and the Sacramento Mountains of New Mexico. The left side faces the Gulf of Mexico and then the Chihuahuan Desert with fewer distinctive landmarks.

During takeoff from Orlando International (MCO), sit on the Right side for the best views. MCO typically departs westbound on runway 18R/36L or uses runways oriented north-south. Climbing out westward, the right (north) side gives you a clear view over the Orlando metro grid, the chain of lakes through the city, and Walt Disney World's distinctive layout visible as a large developed complex southwest of the city. The left side faces south toward open flatlands with less to see. Notable sights include: Walt Disney World resort complex, Orlando's downtown lake chain (Lake Eola area), Lake Apopka to the northwest, Interstate highway grid of greater Orlando.

When landing at Los Angeles International (LAX), sit on the Right side for the best views. LAX primarily lands eastbound on runways 24L/24R or 25L/25R, meaning the aircraft approaches from over the Pacific. On the right (north) side you get the Santa Monica Bay coastline, the Santa Monica Mountains, and the sprawling LA basin grid. The left side faces south toward the Palos Verdes Peninsula and the South Bay, which is less dramatic. Notable sights include: Santa Monica Bay and coastline, Santa Monica Mountains, Los Angeles basin urban grid, Malibu coastline to the north.

The flight from Orlando International (MCO) to Los Angeles International (LAX) takes Approximately 4 hours 45 minutes to 5 hours 15 minutes.

After crossing the Florida panhandle, the route passes over the Gulf Coast of Alabama and Mississippi briefly, then crosses Louisiana and Texas. Notable features include the Mississippi River delta region, the sprawling Texas Hill Country, the Guadalupe Mountains on the Texas-New Mexico border, the White Sands region of southern New Mexico visible as a bright white patch, the Sonoran Desert of Arizona, and the Colorado River before descending into the LA basin.