Sit on the Left side of the plane for the best views on flights from Miami to Mexico City. The left side misses the Florida Keys at takeoff but delivers the Yucatan Peninsula coastline over the Gulf of Mexico mid-flight and the spectacular volcanic approach into Mexico City. The snow-capped Popocatépetl and Iztaccíhuatl on final approach alone make the left side the stronger choice for the full journey.

During takeoff from Miami International (MIA), sit on the Right side for the best views. MIA primarily departs eastward on runways 08L/08R, then aircraft turn southwest toward Mexico City. The right side faces south over Biscayne Bay, the Florida Keys chain, and the shallow turquoise waters of Florida Bay. The left side gets downtown Miami briefly but then faces inland over the Everglades. Notable sights include: Biscayne Bay, the Florida Keys arc stretching southwest, Florida Bay's shallow tidal flats, and the edge of the Everglades wetland mosaic.

When landing at Licenciado Benito Juarez International (MEX), sit on the Left side for the best views. Mexico City's main arrival from the northeast on runway 05L/05R puts the left side facing northwest toward the Sierra Nevada volcanic chain, including Popocatépetl and Iztaccíhuatl. These are among the most dramatic and recognizable peaks in North America, snow-capped and rising above the Valley of Mexico smog layer. Notable sights include: Popocatépetl volcano, Iztaccíhuatl volcano, the Valley of Mexico urban sprawl, and Texcoco lakebed (former lake, now dry salt flat east of the city).

The flight from Miami International (MIA) to Licenciado Benito Juarez International (MEX) takes Approximately 3 hours 15 minutes.

The flight crosses the Gulf of Mexico, passing over or near the Yucatan Peninsula and the Gulf of Campeche. Passengers may see the shallow turquoise waters of the Yucatan shelf, the coastline near Cancun or Merida depending on routing, and the flat jungle interior of the Yucatan. Further along, the terrain rises into the Sierra Madre Oriental foothills before descending into the high central plateau of Mexico.