Sit on the Left side of the plane for the best views on flights from Panama City to Guayaquil. The descent into Guayaquil on the left offers more dramatic and sustained views of the Andes transition and river estuary. The takeoff view is pleasant but brief; the landing approach provides longer visual engagement with distinctive geography.

During takeoff from Tocumen International (PTY), sit on the Right side for the best views. Tocumen typically departs eastbound (Runway 03R/03L). Right-side seats face toward the Caribbean coast and the Panama Canal approach channels as you climb. You'll see the Gatun Lake system and the canal's northern locks infrastructure receding beneath you. Notable sights include: Panama Canal (Gatun Locks), Gatun Lake, Caribbean coastline, Colón province lowlands.

When landing at Simon Bolivar International (GYE), sit on the Left side for the best views. GYE typically lands westbound (Runway 09). Left-side seats face toward the Andes foothills and the Guayas River estuary during descent. You'll see the dramatic transition from Pacific coastal plains to the western cordillera, with the river system and mangrove zones clearly visible. Notable sights include: Guayas River estuary, Andes western cordillera, Pacific coastal plains, Guayaquil city sprawl.

The flight from Tocumen International (PTY) to Simon Bolivar International (GYE) takes Approximately 1 hour 15 minutes.

The flight path crosses the Pacific coast of Colombia and Ecuador. Notable features include the Baudó mountain range (western cordillera of Colombia) visible to the left around midpoint, the Chocó region's dense jungle canopy, and the transition from Colombian Pacific lowlands to Ecuadorian coastal plains. The Pacific Ocean dominates the right side throughout most of the flight. No major cities are directly on the route, but the coastline remains visible for much of the journey.