Sit on the Left side of the plane for the best views on flights from Santo Domingo to Boston. The left seat wins overall because the departure from Santo Domingo offers the most visually rich content — the city, the river, and the Cordillera Central — and during the cruise northward the left side tracks closer to the eastern seaboard of the US as the flight arcs over the Atlantic. The Boston arrival on the right is excellent, but the departure scenery is more distinctive and harder to replicate.

During takeoff from Las Americas International (SDQ), sit on the Left side for the best views. SDQ's primary departure runway is 17/35, with northbound departures on Runway 35 taking the aircraft over the coast and then out over the Caribbean. A left seat faces west during the initial climb, giving views of Santo Domingo city, the Ozama River mouth, and the colonial zone waterfront. Right seat gets open ocean early. Notable sights include: Santo Domingo colonial zone and Ozama River mouth, Cordillera Central peaks to the northwest, Caribbean coastline stretching west toward Barahona, Lake Enriquillo basin visible in the distance to the west-southwest.

When landing at General Edward Lawrence Logan International (BOS), sit on the Right side for the best views. Logan Airport sits on a peninsula in Boston Harbor, and aircraft typically approach from the south or southwest on Runway 04R/04L or 22L/22R depending on wind. A southerly approach over the harbor gives the right side views of Boston Harbor islands, the downtown skyline, and the Charles River basin. Left side faces inland toward suburban sprawl. Notable sights include: Boston Harbor and its island chain, downtown Boston skyline including the Financial District, Charles River and Cambridge across the river, Cape Cod peninsula visible to the southeast on clear days.

The flight from Las Americas International (SDQ) to General Edward Lawrence Logan International (BOS) takes Approximately 4 hours 15 minutes to 4 hours 45 minutes.

The flight tracks north-northeast over the Atlantic, passing east of the Turks and Caicos Islands and the Bahamas chain early in the flight. The Gulf Stream is crossed roughly over open ocean east of the Carolinas. The mid-Atlantic US coastline — Cape Hatteras, the Outer Banks, and eventually the New Jersey shore — becomes visible on the left side during descent. Cape Cod and the Massachusetts coastline appear on the right as the aircraft approaches Boston.