Sit on the Left side of the plane for the best views on flights from Boston to Cincinnati. Left side wins both ends of this flight. At departure you get Boston Harbor and the city skyline; at arrival you get the Ohio River valley and Cincinnati. Along the cruise portion heading southwest, the left side also faces more toward the Catskills and Appalachian ridgelines of Pennsylvania and West Virginia as you cross them, giving better terrain views than the right side's flatter perspective.

During takeoff from General Edward Lawrence Logan International (BOS), sit on the Left side for the best views. Logan's primary departure runway for westbound flights is typically Runway 22L/22R, heading southwest. A left-side seat gives you a clear view back over Boston Harbor, the downtown skyline, and the Charles River as you climb out over the water. The city grid and harbor islands are laid out clearly below before you turn west. Notable sights include: Boston Harbor and Harbor Islands, Downtown Boston skyline, Charles River and Cambridge, Quincy Bay.

When landing at Cincinnati Northern Kentucky International (CVG), sit on the Left side for the best views. CVG typically uses Runway 18L/18C for southbound arrivals or Runway 36 for northbound, but the most common approach from the east is Runway 18, heading south. A left-side seat on approach from the east gives you a view over the Ohio River valley, the Cincinnati skyline across the river in Ohio, and the Kentucky hills rolling beneath you. The river's wide bend and the urban core are clearly visible on the left. Notable sights include: Ohio River and its wide bend north of the airport, Cincinnati downtown skyline across the river, Northern Kentucky suburban grid, Kentucky hills and river bluffs.

The flight from General Edward Lawrence Logan International (BOS) to Cincinnati Northern Kentucky International (CVG) takes Approximately 2 hours 10 minutes.

The flight tracks southwest across central Massachusetts, then over the Hudson Valley in New York, crossing the Catskill Mountains and then the folded ridge-and-valley Appalachians of central Pennsylvania — the parallel ridges of the Ridge and Valley province are strikingly visible from altitude. The route then crosses over the Allegheny Plateau into Ohio before descending into the Ohio River valley at Cincinnati.