Sit on the Right side of the plane for the best views on flights from Boston to St. Louis. The right side wins overall. The Boston departure from the right gives you the full harbor and city skyline spectacle during the most visually interesting phase of flight. The left side advantage at STL landing is real but the Arch is a brief moment. Right side also tracks better along the flight path for views of the Berkshires and upstate New York terrain during cruise.

During takeoff from General Edward Lawrence Logan International (BOS), sit on the Right side for the best views. Logan's most common departure runway is 22L/22R heading southwest, which puts the right side facing northwest toward downtown Boston, the Charles River, and Cambridge. You get a clear look at the city skyline and harbor islands as the aircraft climbs out over the water. Notable sights include: Boston downtown skyline, Boston Harbor and harbor islands, Charles River and Cambridge, Quincy Bay.

When landing at Lambert St Louis International (STL), sit on the Left side for the best views. Lambert STL typically uses runways 12L/12R or 30L/30R depending on wind. On the common westerly approach to runway 12, the left side faces south toward the Gateway Arch, the Mississippi River, and the St. Louis urban core. The Arch is a genuinely distinctive and unmistakable landmark visible from several miles out on approach. Notable sights include: Gateway Arch and downtown St. Louis, Mississippi River, Missouri River confluence north of the city, Cahokia Mounds area across the river in Illinois.

The flight from General Edward Lawrence Logan International (BOS) to Lambert St Louis International (STL) takes Approximately 2 hours 45 minutes to 3 hours.

The flight path crosses the Berkshire Hills of western Massachusetts, then the Hudson Valley in New York, before tracking across the relatively flat terrain of Pennsylvania and Ohio. The Allegheny Plateau is visible in central Pennsylvania as rolling forested ridgelines. Indiana and Illinois are predominantly flat agricultural land with the occasional river corridor. The Ohio River may be visible as a winding silver line near the Ohio-Indiana border region depending on exact routing.