Sit on the Right side of the plane for the best views on flights from Boston to Knoxville. The right side wins overall because the Boston Harbor and city skyline departure is one of the more dramatic urban takeoffs on the East Coast, and the right side also tracks the Connecticut River valley and Catskill ridgelines through the mid-flight. The landing view on the left is excellent but the Smokies are often hazy and less dramatic than the Boston departure.

During takeoff from General Edward Lawrence Logan International (BOS), sit on the Right side for the best views. Logan's primary southwest departures (runway 22L/22R) take you over Boston Harbor and the city skyline. The right side gives you a clear look back at downtown Boston, the Financial District, and the Charles River as you bank southwest toward Connecticut. Notable sights include: Boston Harbor and its islands, downtown Boston skyline, Charles River basin, Cape Cod Bay visible to the southeast.

When landing at Mc Ghee Tyson (TYS), sit on the Left side for the best views. McGhee Tyson typically uses runway 23L for southwest arrivals, meaning the approach comes in from the northeast over the Great Smoky Mountains. The left side gives you a sustained view of the Smoky Mountains ridgelines and the Tennessee Valley floor as you descend. Notable sights include: Great Smoky Mountains ridgelines, Tennessee River valley, Knoxville urban area, Clinch River.

The flight from General Edward Lawrence Logan International (BOS) to Mc Ghee Tyson (TYS) takes Approximately 2 hours 10 minutes.

The flight tracks southwest over Connecticut, crossing the Hudson River valley in New York, then over the Catskill Mountains and the Pocono Plateau in Pennsylvania, before descending over the Ridge and Valley Appalachians of Virginia and into the Tennessee Valley. The Shenandoah Valley and Blue Ridge are visible in the mid-flight section over Virginia.