Sit on the Left side of the plane for the best views on flights from Blytheville to Chicago. Left side wins at both ends. The Mississippi River on departure and the Chicago skyline plus Lake Michigan on approach make the left seat clearly superior for the whole flight. The right side offers flat farmland and suburban sprawl with nothing comparable.

During takeoff from Arkansas International (BYH), sit on the Left side for the best views. Arkansas International's primary runway (18/36) means northbound departures head roughly north. A left (west) seat gives you a view back over the Mississippi River floodplain and the river itself as you climb out, which is the dominant geographic feature here. The Mississippi is wide and clearly visible at this location near the Missouri bootheel. Notable sights include: Mississippi River main channel, Mississippi River floodplain agricultural grid, Blytheville city grid below, Missouri bootheel farmland to the northwest.

When landing at Chicago Ohare International (ORD), sit on the Left side for the best views. O'Hare arrivals from the south typically use runways oriented east-west or northwest-southeast. A left (south) seat on approach from the south gives you the Chicago skyline to the southeast, Lake Michigan's shoreline, and the dense urban grid of the city. The right seat faces north toward suburban sprawl with far less visual interest. Notable sights include: Chicago downtown skyline and Willis Tower, Lake Michigan shoreline and southern lakefront, Chicago urban street grid, O'Hare airport complex and surrounding suburbs.

The flight from Arkansas International (BYH) to Chicago Ohare International (ORD) takes Approximately 1 hour to 1 hour 15 minutes.

The flight tracks roughly north-northeast over the Illinois plains — flat agricultural land the entire way. You cross the Cache River wetlands in southern Illinois, then the broad flat corn and soybean fields of central Illinois. The Kaskaskia and Illinois river valleys are faintly visible as slight topographic breaks in the otherwise featureless plain. No significant terrain changes occur; the landscape is uniformly flat from Arkansas to Chicago.