Sit on the Right side of the plane for the best views on flights from Denver to Panama City. The left side wins at takeoff for the Rockies, but the right side delivers the more dramatic and sustained payoff: Gulf of Mexico coastline views over Mexico's Yucatan Peninsula, Caribbean coastal scenery over Central America, and the spectacular Panama City skyline and canal approach on landing. Right side wins the full flight.

During takeoff from Denver International (DEN), sit on the Left side for the best views. DEN typically departs south or southeast on runways 35L/35R or 17L/17R. A southbound departure on runway 17 puts the Rocky Mountain Front Range — including Pikes Peak and the entire Front Range escarpment — directly off the left (east-facing) window as the aircraft banks south. The sprawling Denver metro grid is also clearly visible below. Notable sights include: Rocky Mountain Front Range escarpment, Pikes Peak (14,115 ft) to the south, Denver metro grid, Chatfield Reservoir.

When landing at Tocumen International (PTY), sit on the Right side for the best views. Tocumen International typically lands on runway 03R/21L or 10/28. On the common approach from the north, aircraft track south over the Isthmus of Panama, and the right side offers views of Panama City's skyline, the Bay of Panama, and the Pacific entrance to the Panama Canal. The Miraflores Locks and the Bridge of the Americas are genuinely visible on clear days from the right side during descent. Notable sights include: Panama City skyline (Punta Pacifica/Miraflores district), Bay of Panama, Panama Canal Pacific entrance, Bridge of the Americas.

The flight from Denver International (DEN) to Tocumen International (PTY) takes Approximately 6 to 6.5 hours.

The flight tracks southeast over New Mexico and Texas, crossing the Gulf of Mexico near the Yucatan Peninsula. The turquoise shallow waters of the Yucatan shelf and the Caribbean coast of Belize and Guatemala are visible mid-flight. The route then crosses Honduras and Costa Rica's mountainous interior before descending over the narrow Isthmus of Panama, where both the Pacific and Caribbean coasts are sometimes simultaneously visible.