Sit on the Left side of the plane for the best views on flights from Detroit to Mexico City. While takeoff favors the right for Great Lakes views, the landing approach into Mexico City offers more dramatic and sustained scenery on the left—the Sierra de Guadalupe, the valley geography, and potential volcano views outweigh the brief takeoff advantage.

During takeoff from Detroit Metro Wayne Co (DTW), sit on the Right side for the best views. DTW typically departs eastbound (Runways 03L/03R or 21L/21R depending on wind). Right-side seats offer views of Lake St. Clair and the Detroit River delta as you climb out over southeastern Michigan, with the urban sprawl of Detroit visible to the left but less dramatic. Notable sights include: Lake St. Clair (immediate northeast), Detroit River and Windsor, Ontario (across the border), Lake Erie (distant southeastern horizon).

When landing at Licenciado Benito Juarez International (MEX), sit on the Left side for the best views. Approaching MEX typically uses Runways 05L/05R or 09L/09R (eastbound or southbound depending on wind). Left-side seats during descent offer views of the Valley of Mexico, the Sierra de Guadalupe mountains to the north, and Texcoco Lake bed. Right side shows less distinctive terrain. Notable sights include: Sierra de Guadalupe (northern rim of valley), Texcoco Lake bed (dried lakebed east of city), Mexico City urban sprawl, Popocatépetl volcano (distant southern horizon on clear days).

The flight from Detroit Metro Wayne Co (DTW) to Licenciado Benito Juarez International (MEX) takes Approximately 3 hours 45 minutes to 4 hours 15 minutes.

The flight path crosses southern Michigan, Indiana, and Illinois before heading south over Kentucky and Tennessee. Notable features include the Ohio River valley (visible around midpoint if flying at 25,000+ feet), the Appalachian foothills receding to the east, and the Mississippi River valley to the west. As you approach Mexico, the Sierra Madre Oriental mountains become visible on the eastern horizon, and the high plateau of central Mexico gradually rises beneath you before descent into the Valley of Mexico.