Sit on the Right side of the plane for the best views on flights from Rome to Boston. The right side delivers the most dramatic single moment of the flight — the sweeping view of Rome's historic center during climb-out, which is genuinely one of the great urban aerial views in the world. The Boston approach on the left is excellent but briefer. Right side also tracks the southern coast of Ireland and Cornwall during the transatlantic crossing, offering occasional coastal glimpses.

During takeoff from Fiumicino (FCO), sit on the Right side for the best views. FCO typically departs on runway 16R/16L heading south, then aircraft turn northeast over Rome. Right side passengers get a clear view of central Rome including the Tiber River bends, the Colosseum area, and Vatican City as the plane banks left climbing out. Left side faces the Tyrrhenian Sea and coastal flats. Notable sights include: Vatican City and St. Peter's Square, Tiber River bends through central Rome, Colosseum and Roman Forum district, Apennine Mountains rising to the east.

When landing at General Edward Lawrence Logan International (BOS), sit on the Left side for the best views. Logan Airport sits on a peninsula in Boston Harbor, and aircraft typically approach from the southwest on runway 04L/04R or from the northwest on runway 33L. On a standard approach from the southwest, left side passengers see Boston Harbor, the downtown skyline, and Cape Cod Bay in the distance. Right side faces the South Shore suburbs. Notable sights include: Boston downtown skyline and Back Bay, Boston Harbor islands, Charles River and Cambridge, Cape Cod peninsula visible to the south on clear days.

The flight from Fiumicino (FCO) to General Edward Lawrence Logan International (BOS) takes Approximately 9 to 10 hours.

After departing Rome the route crosses the northern Apennines and Po Valley, then tracks northwest over the Alps near the Mont Blanc massif visible to the south. The flight crosses southern France, then the English Channel near Brittany or Cornwall. The transatlantic leg crosses Ireland's west coast, then the open North Atlantic with occasional iceberg-bearing waters south of Greenland. The Canadian Maritime provinces — Nova Scotia and Cape Breton — appear before the final descent into Boston over the Gulf of Maine.