Sit on the Left side of the plane for the best views on flights from Guayaquil to Santiago. Left side captures the Andes throughout the descent into Santiago, the dominant geographic feature of this route. Takeoff favors right, but landing's superior Andes views and the mountain range's presence for most of the southern portion of the flight make left the better overall choice.

During takeoff from Simon Bolivar International (GYE), sit on the Right side for the best views. GYE typically departs eastbound (runways 09/27, favoring 09 for prevailing winds). Right-side seats capture the Andes rising dramatically inland as you climb, with the coastal plain and Pacific receding behind. Left side shows only ocean. Notable sights include: Andes cordillera (eastern horizon), Guayas River delta (beneath during initial climb), Pacific coastline, foothills of western Ecuador.

When landing at Arturo Merino Benitez International (SCL), sit on the Left side for the best views. SCL approaches from the north, typically landing on runways 34L/34R (northbound final). Left-side seats offer unobstructed views of the Andes as you descend into the Central Valley, with the Maipo River gorge and Santiago's urban sprawl visible. Right side faces away from the mountains. Notable sights include: Andes cordillera (dominant, left side), Central Valley floor, Maipo River canyon, Santiago metropolitan area.

The flight from Simon Bolivar International (GYE) to Arturo Merino Benitez International (SCL) takes Approximately 3 hours 15 minutes.

Flight path crosses the Andes at roughly 12,000-14,000 feet, passing over high-altitude valleys and peaks in southern Ecuador and northern Peru. The Marañón River drainage basin is visible from altitude in the midpoint. Descent into Chile occurs over the high Andean plateau before dropping into the Central Valley. No major cities are directly on the route, but the Andes dominate the entire southern half of the flight.