Sit on the Left side of the plane for the best views on flights from Mendoza to Santiago. While takeoff favors the right for Andes views, the landing approach on runway 35 is the dominant visual event on this route. Left-side seats capture the full Cordillera de Santiago descent and the dramatic final approach to SCL, which outweighs the takeoff advantage.

During takeoff from El Plumerillo (MDZ), sit on the Right side for the best views. MDZ typically departs runway 04 (northeast) or 22 (southwest). Right-side seats capture the Andes spine immediately after liftoff, with the high peaks of the Cordillera Principal rising sharply to the east. Left seats see the flat Cuyo plain extending westward—less dramatic. Notable sights include: Cordillera Principal (eastern wall of the Andes), Aconcagua massif region (visible as the highest peaks on the horizon), Tunuyán River valley (dark linear feature below), Mendoza city grid (receding westward).

When landing at Arturo Merino Benitez International (SCL), sit on the Left side for the best views. SCL uses runway 35L/35R for most arrivals from the east. Left-side seats provide the clearest view of the Andes approach—the Cordillera de Santiago and the San Cristóbal peak dominate the descent path. Right seats see the flat Central Valley and Santiago's sprawl but miss the mountain drama. Notable sights include: Cordillera de Santiago (the high ridge immediately east of the city), San Cristóbal peak (the prominent cone on the eastern skyline), Mapocho River valley (the linear depression running north-south through Santiago), Santiago metropolitan area (urban grid expanding westward from the mountain base).

The flight from El Plumerillo (MDZ) to Arturo Merino Benitez International (SCL) takes Approximately 1 hour 15 minutes.

The flight crosses the high Andes crest between Aconcagua (6,961 m) and the Cordillera de Santiago. At cruise altitude (around 28,000 feet), passengers see the continuous snow-capped ridge of the Cordillera Principal running north-south, with deep valleys cutting east-west between major peaks. The Río Maipo and Río Cachapoal drainage systems are visible as dark linear features cutting through the high terrain. The transition from the arid Cuyo region (east) to the slightly greener Central Valley (west) is marked by the mountain crest. No major cities are visible at cruise altitude, but the geography is dominated by the unbroken Andes wall.