Sit on the Right side of the plane for the best views on flights from Philadelphia to St. Louis. Right-side seats provide superior scenery at both ends of the flight—Philadelphia's rivers and urban core on takeoff, and the Mississippi River valley and St. Louis landmarks on descent. The westbound routing also favors right-side views of the Appalachian foothills during cruise.

During takeoff from Philadelphia International (PHL), sit on the Right side for the best views. Right-side seats capture the Delaware River and Philadelphia's urban core as you climb westward. The river's distinctive curves and the city's grid layout are clearly visible during the initial climb-out before heading inland. Notable sights include: Delaware River, Philadelphia downtown skyline, Schuylkill River, Ben Franklin Bridge.

When landing at Lambert St Louis International (STL), sit on the Left side for the best views. Left-side seats offer the best view of St. Louis's defining landmark—the Gateway Arch—as you descend into Lambert. The Mississippi River's wide channel and the city's position on its banks are also clearly visible during final approach. Notable sights include: Gateway Arch, Mississippi River, St. Louis downtown, Illinois bluffs across the river.

The flight from Philadelphia International (PHL) to Lambert St Louis International (STL) takes Approximately 2 hours 45 minutes.

The flight path crosses the Appalachian Mountains' western ridges (visible as low, forested ridges rather than dramatic peaks), the Ohio River valley near its confluence with the Wabash River, and the flat terrain of Indiana and Illinois. The Cumberland Plateau's eastern edge appears as subtle elevation changes around the Pennsylvania-West Virginia border. Most of the cruise segment crosses relatively flat, agricultural terrain with scattered towns and river valleys.