Sit on the Right side of the plane for the best views on flights from Knoxville to Minneapolis. The right side captures the most visually distinctive segment—the Great Smoky Mountains during climb-out—which is more dramatic and memorable than the relatively flat Minnesota approach. The Smokies provide sustained scenic interest for the first 20–30 minutes of flight.

During takeoff from Mc Ghee Tyson (TYS), sit on the Right side for the best views. Right-side seats offer views of the Great Smoky Mountains as the aircraft climbs northwestward from Knoxville. The ridgelines and valleys of the Smokies are prominent during the initial 10–15 minutes of climb, providing dramatic topography against the valley floor. Notable sights include: Great Smoky Mountains (southeast to south), Tennessee River valley (west), Knoxville urban area (immediate vicinity), foothills of the Cumberland Plateau (northwest distance).

When landing at Minneapolis St Paul International (MSP), sit on the Left side for the best views. Left-side seats provide views of the Minnesota River valley and the Minneapolis-St. Paul urban corridor during descent. The Twin Cities sprawl, the Minnesota River, and the surrounding prairie landscape are visible on approach from the south and southeast. Notable sights include: Minnesota River valley (west and northwest), Minneapolis-St. Paul metropolitan area (north and northeast), Mississippi River (visible near downtown Minneapolis), prairie and agricultural land (surrounding terrain).

The flight from Mc Ghee Tyson (TYS) to Minneapolis St Paul International (MSP) takes 3h 15m.

Ohio River valley (southern Ohio), Appalachian foothills and ridges (eastern Kentucky and southern Ohio), transition to flatter terrain across Indiana and Illinois, Mississippi River valley (western Illinois and eastern Iowa), agricultural plains of Iowa and southern Minnesota