Sit on the Left side of the plane for the best views on flights from Denver to Buffalo. Left side wins both departure and arrival. At takeoff you get the full Rocky Mountain Front Range panorama, and on approach you get Lake Erie, the Niagara River, and a chance to spot Niagara Falls. The right side offers plains on departure and Lake Ontario on arrival — both less visually compelling.

During takeoff from Denver International (DEN), sit on the Left side for the best views. DEN typically departs east on runway 16R/34L or 17R/35L, then turns northeast toward Buffalo. A left (north-facing) window captures the Front Range of the Rockies — including Longs Peak and the entire mountain wall — as the aircraft climbs and banks. The city of Denver and its grid also spreads out clearly to the left during the initial climb. Notable sights include: Front Range of the Rocky Mountains (Longs Peak, Mount Evans visible), Denver city grid and downtown skyline, Cherry Creek Reservoir southeast of downtown, Rocky Mountain Arsenal National Wildlife Refuge.

When landing at Buffalo Niagara International (BUF), sit on the Left side for the best views. Buffalo Niagara typically lands on runway 23, approaching from the northeast over Lake Ontario and the Niagara Peninsula. A left window faces south and gives a direct view of Lake Erie, the Niagara River corridor, and Niagara Falls itself as the aircraft descends. The right side faces north over Lake Ontario with less distinctive geography. Notable sights include: Lake Erie stretching to the southwest, Niagara River connecting Lake Erie to Lake Ontario, Niagara Falls (visible as a mist plume and the gorge), Buffalo city waterfront on Lake Erie.

The flight from Denver International (DEN) to Buffalo Niagara International (BUF) takes Approximately 3 hours 15 minutes.

The flight tracks northeast across the Nebraska and Iowa plains, then over the Great Lakes region. Notable features include the Missouri River valley crossing near Omaha, the Mississippi River crossing near the Iowa-Illinois border, Lake Michigan visible to the north as the route passes over northern Indiana, and the southern shore of Lake Erie as the flight descends into Buffalo.