Sit on the Right side of the plane for the best views on flights from Newark to Mexico City. While the left side wins at takeoff with the Manhattan skyline, the right side delivers more sustained views during the flight. Over the Gulf of Mexico coast and through central Mexico, the right side tracks the Sierra Madre Oriental and eventually the volcanic peaks approaching Mexico City. The Popocatepetl and Iztaccihuatl approach view on the right is one of the most dramatic arrival sequences in commercial aviation.

During takeoff from Newark Liberty International (EWR), sit on the Left side for the best views. EWR's primary departure runway 22L sends aircraft southwest over New Jersey, and a left-side seat faces southeast toward New York Harbor, Lower Manhattan, and the Statue of Liberty. The entire Manhattan skyline is visible across the Hudson as you climb out, with Brooklyn and the Verrazano-Narrows Bridge extending south. Notable sights include: Manhattan skyline, Statue of Liberty in New York Harbor, Verrazano-Narrows Bridge, Newark Bay.

When landing at Licenciado Benito Juarez International (MEX), sit on the Right side for the best views. Mexico City's main arrival runway 05R brings aircraft in from the southwest, meaning a right-side seat faces north and northwest toward the Sierra Nevada volcanic chain. Popocatepetl and Iztaccihuatl are clearly visible as snow-capped peaks rising above the Valley of Mexico on descent, and the vast urban grid of Mexico City spreads across the basin below. Notable sights include: Popocatepetl volcano, Iztaccihuatl volcano, Valley of Mexico urban basin, Lake Texcoco remnant wetlands.

The flight from Newark Liberty International (EWR) to Licenciado Benito Juarez International (MEX) takes Approximately 5 hours 30 minutes.

The flight tracks southwest over the Appalachians briefly, then crosses the Gulf of Mexico. Over Mexico, the route passes over the Sierra Madre Oriental range in Tamaulipas and Nuevo Leon, the high central Mexican plateau, and the Trans-Mexican Volcanic Belt including the Cofre de Perote and Pico de Orizaba before descending into the Valley of Mexico.