Sit on the Left side of the plane for the best views on flights from Newark to New Orleans. The left side delivers the most dramatic single moment of the flight — the full Manhattan skyline and Statue of Liberty on departure — which outweighs the right side's Lake Pontchartrain approach view. During cruise, the flight tracks southwest over the Appalachian foothills, Tennessee, and Mississippi, with neither side offering a decisive advantage, but the departure spectacle makes left the clear overall winner.

During takeoff from Newark Liberty International (EWR), sit on the Left side for the best views. EWR typically departs south on runway 22L/22R or north on runway 4L/4R. On southbound departures, the left side gets a direct view of Lower Manhattan, the Statue of Liberty, and New York Harbor. On northbound departures, left side still captures the Manhattan skyline as the aircraft banks southwest toward the route. Notable sights include: Manhattan skyline, Statue of Liberty in New York Harbor, Verrazano-Narrows Bridge, Newark Bay.

When landing at Louis Armstrong New Orleans International (MSY), sit on the Right side for the best views. MSY sits north of New Orleans, and aircraft typically approach from the northeast on runway 10 or from the east on runway 20. On these approaches, the right side gives views of Lake Pontchartrain, the Lake Pontchartrain Causeway, and the distinctive crescent bend of the Mississippi River through the city. Notable sights include: Lake Pontchartrain, Lake Pontchartrain Causeway, Mississippi River crescent through New Orleans, the French Quarter and downtown New Orleans grid.

The flight from Newark Liberty International (EWR) to Louis Armstrong New Orleans International (MSY) takes Approximately 3 hours 15 minutes.

The flight path crosses the Appalachian ridges of Virginia and West Virginia (visible as parallel forested ridgelines), the Tennessee Valley, the Cumberland Plateau, then descends over the flat Mississippi Delta lowlands and the broad Mississippi River floodplain approaching Louisiana. The Mississippi River itself may be visible multiple times as the route crosses it near Memphis or further south.