Sit on the Left side of the plane for the best views on flights from Newark to Mexicali. The left side delivers the spectacular New York Harbor and Manhattan skyline departure, which is one of the most iconic urban aerial views in the world. The landing views on the right are interesting but relatively modest — flat desert and agricultural fields. The takeoff experience on the left is the highlight of this flight.

During takeoff from Newark Liberty International (EWR), sit on the Left side for the best views. EWR's primary departure runway 22L sends aircraft southwest over New Jersey, and the left side gets a direct view back over Newark Bay, the Manhattan skyline, and Upper New York Bay as the aircraft climbs and banks. The right side faces inland New Jersey with far less visual interest. Notable sights include: Manhattan skyline, Newark Bay, Verrazano-Narrows Bridge, Upper New York Bay.

When landing at General Rodolfo Sanchez Taboada International (MXL), sit on the Right side for the best views. Mexicali's runway 26 approach brings aircraft in from the east heading west, placing the right side with a view south into the Mexicali Valley and the agricultural patchwork of the Valle de Mexicali, while also offering views of the Sierra de los Cucapah range to the south. The left side looks north into the Sonoran Desert scrubland with less visual distinction. Notable sights include: Mexicali urban grid, Valle de Mexicali agricultural fields, Sierra de los Cucapah, Colorado River delta region.

The flight from Newark Liberty International (EWR) to General Rodolfo Sanchez Taboada International (MXL) takes Approximately 5 hours 30 minutes to 6 hours.

The flight tracks southwest across Pennsylvania and West Virginia, then over Tennessee and Arkansas, crossing the Mississippi River near Memphis. It continues over Texas, passing north of Dallas-Fort Worth, then over the Chihuahuan Desert of west Texas and New Mexico before crossing into Sonora, Mexico, and descending into the Colorado River basin at Mexicali. The Appalachians are visible early in the flight, and the flat Great Plains dominate the middle section before the Basin and Range terrain of the Southwest appears near the end.