Sit on the Left side of the plane for the best views on flights from Newark to Panama City. Left side wins both ends of the flight. During the cruise over the Caribbean, the left side also offers views of the Colombian and Venezuelan coastlines as the route tracks south, making it the consistently better side throughout.

During takeoff from Newark Liberty International (EWR), sit on the Left side for the best views. EWR departures heading south on runway 22L/22R put Manhattan directly on the left side. You get a clear view of the Hudson River, the Manhattan skyline, and the Statue of Liberty in the harbor as the aircraft climbs out over New Jersey. Notable sights include: Manhattan skyline, Hudson River, Statue of Liberty in New York Harbor, Verrazano-Narrows Bridge.

When landing at Tocumen International (PTY), sit on the Left side for the best views. Tocumen sits east of Panama City, and aircraft typically approach from the east on runway 03L/03R or from the north, putting the Pacific coast, Panama City skyline, and the Panama Canal's Pacific entrance on the left side during descent. The Bridge of the Americas and the canal locks are genuinely visible from the left on approach. Notable sights include: Panama City skyline, Bridge of the Americas, Panama Canal Pacific entrance at Miraflores, Pacific Ocean coastline.

The flight from Newark Liberty International (EWR) to Tocumen International (PTY) takes Approximately 5 hours 15 minutes to 5 hours 45 minutes.

The flight tracks south over the Atlantic off the US East Coast, then crosses Cuba or the western Caribbean Sea, passes over or near the Colombian coast, and descends over the Darien region of eastern Panama. The Sierra Maestra mountains of eastern Cuba may be visible, and the Colombian Andes foothills appear as the route approaches Panama. The dense green Darien Gap jungle is visible on descent.