Sit on the Left side of the plane for the best views on flights from Newark to St. Louis. Left side delivers the best views at both ends of the flight — Manhattan and the Statue of Liberty on departure, and the Gateway Arch with the Mississippi River on approach. The mid-flight portion over Pennsylvania, Ohio, and Indiana is relatively flat and featureless at cruising altitude, so the departure and arrival windows matter most.

During takeoff from Newark Liberty International (EWR), sit on the Left side for the best views. EWR's primary departure runways (22L/22R) head southwest, putting Manhattan and the Hudson River on the left side during climb-out. You get a direct broadside view of Lower Manhattan, the Hudson, and the Statue of Liberty before the aircraft turns west. Notable sights include: Manhattan skyline (Lower Manhattan and Midtown), Hudson River, Statue of Liberty on Liberty Island, Newark Bay.

When landing at Lambert St Louis International (STL), sit on the Left side for the best views. STL's primary arrival runways (12L/12R) bring aircraft in from the northwest, placing the Gateway Arch and downtown St. Louis on the left side during final approach. The Mississippi River is clearly visible as the natural boundary between Missouri and Illinois. Notable sights include: Gateway Arch and downtown St. Louis, Mississippi River, Missouri River confluence north of the city, East St. Louis Illinois floodplain.

The flight from Newark Liberty International (EWR) to Lambert St Louis International (STL) takes Approximately 2 hours 30 minutes.

The flight tracks roughly west-southwest across northern Pennsylvania's rolling Appalachian ridges (visible as parallel forested folds early in the cruise), then flattens out over eastern Ohio and Indiana's agricultural grid. The Ohio River may be visible as a dark ribbon near the Indiana-Illinois border. The final descent crosses the flat Illinois prairie before the Mississippi River comes into view.