Sit on the Right side of the plane for the best views on flights from Frankfurt to Cairo. While the left side offers a decent Frankfurt departure view, the right side wins overall. It captures the eastern Alps during the cruise over Austria, the Greek islands and Aegean Sea in the middle portion of the flight, and most critically delivers the Giza Pyramids and Nile on approach into Cairo — the most dramatic single landmark on the entire route.

During takeoff from Frankfurt Main (FRA), sit on the Left side for the best views. Frankfurt departures on runway 25C/25L head westward before turning south, putting the left side facing south over the Rhine-Main region. You get a clear view of Frankfurt's city center skyline and the Main River bending through the city as you climb out. Notable sights include: Frankfurt city skyline (Bankenviertel skyscrapers), Main River curve through the city, Taunus hills to the north, Rhine River confluence near Mainz.

When landing at Cairo International (CAI), sit on the Right side for the best views. Cairo International sits northeast of the city center, and aircraft typically approach from the north on runway 05R/05L heading northeast, or from the northeast on runway 23. On approach from the north, the right side faces west over Cairo's urban sprawl, the Nile, and the Giza Plateau with the pyramids clearly visible in the desert to the southwest of the city. Notable sights include: Giza Pyramids on the desert plateau southwest of Cairo, Nile River splitting through Cairo, Cairo urban grid, Lake Qarun visible to the southwest on clear days.

The flight from Frankfurt Main (FRA) to Cairo International (CAI) takes Approximately 4 hours 15 minutes.

The route tracks southeast from Frankfurt over Bavaria and the Austrian Alps (Salzburg region), then over the Adriatic Sea near Croatia, across Greece including the Peloponnese and Aegean islands, over Crete, then across the eastern Mediterranean before crossing the Egyptian coast near Alexandria and descending toward Cairo over the Nile Delta.