Sit on the Left side of the plane for the best views on flights from Frankfurt to Heraklion. Left side wins both ends of the flight. During the cruise phase, the left side also faces south as the route tracks southeast over Austria, Slovenia, and the Adriatic, giving views toward the Alps on departure and the Greek island chains on descent. The right side faces north for most of the flight, which is less interesting over open Adriatic and Ionian waters.

During takeoff from Frankfurt Main (FRA), sit on the Left side for the best views. Frankfurt uses runways 07L/07R or 25L/25R depending on wind. On the dominant westerly departure (runway 07, heading east then turning southeast), the left side gives you the Frankfurt city skyline and the Main River valley. On runway 25 departures heading west then turning south, left side still captures the Taunus hills and the city receding behind you. Notable sights include: Frankfurt city skyline (Bankenviertel towers), Main River bends, Taunus hills to the northwest, Rhine-Main flatlands.

When landing at Nikos Kazantzakis (HER), sit on the Left side for the best views. Heraklion's runway 09/27 runs roughly east-west parallel to the northern Cretan coast. Aircraft typically land from the west on runway 09 (heading east), which puts the left side facing north over the Sea of Crete and the right side over the island interior. However, on runway 27 approach from the east heading west, the left side faces south and gives you the Psiloritis massif (Mount Ida, 2,456m) dominating central Crete, which is the more dramatic view. Left wins overall for the mountain interior on the more common easterly approach as well, where you can see the Dikti range. Notable sights include: Mount Psiloritis (Ida) massif, Dikti mountain range, Heraklion city and harbor, Sea of Crete coastline.

The flight from Frankfurt Main (FRA) to Nikos Kazantzakis (HER) takes Approximately 3 hours 15 minutes.

The route passes over the Austrian Alps (Salzburg region), then crosses Slovenia and Croatia, the Adriatic Sea between Split and the Dalmatian islands, then over the Ionian Sea before crossing the Greek mainland near Patras and the Gulf of Corinth, then over the Aegean before descending toward Crete. The Dalmatian island chain is particularly visible mid-flight.