Sit on the Right side of the plane for the best views on flights from Frankfurt to Fort Myers. The right side wins overall. While the left side has the better Frankfurt departure view, the right side delivers the spectacular Gulf Coast arrival into RSW with Sanibel, Estero Bay, and the barrier islands. During the transatlantic crossing the right side also faces south toward the Azores region and gets better light angles in the afternoon. The Fort Myers arrival view is the visual highlight of the whole flight.

During takeoff from Frankfurt Main (FRA), sit on the Left side for the best views. Frankfurt departures on runway 25L/25C head westbound, putting the left side facing south toward the Rhine-Main plain and the Taunus hills. You get a clear view of the Main River bending through Frankfurt's city center and the distinctive skyline of Bankenviertel before climbing out over the Taunus ridge. Notable sights include: Frankfurt Bankenviertel skyline, Main River bend, Taunus hills, Rhine valley near Mainz.

When landing at Southwest Florida International (RSW), sit on the Right side for the best views. RSW sits east of Fort Myers and aircraft typically approach from the east or northeast on runway 06/24. A right-side seat on approach from the northeast gives you the Gulf of Mexico coastline, Estero Bay, and the barrier islands of Sanibel and Captiva laid out clearly to the west and southwest. Notable sights include: Sanibel Island, Estero Bay, Caloosahatchee River, Fort Myers Beach barrier island.

The flight from Frankfurt Main (FRA) to Southwest Florida International (RSW) takes Approximately 10 to 11 hours westbound.

The flight tracks westbound over the English Channel or southern England, then across the North Atlantic roughly between 45N and 55N latitude passing well north of the Azores. Mid-ocean there is little to see beyond open Atlantic. Approaching North America the route descends over Newfoundland or Nova Scotia, then tracks southwest along the US East Coast corridor passing over or near the Carolinas and Georgia before turning toward Florida. The Gulf Stream is occasionally visible as a color change in the ocean surface on the approach to the US coast.