Sit on the Right side of the plane for the best views on flights from London to Prague. The right side wins overall because the London departure view is genuinely spectacular — the Thames and city skyline are hard to beat — and during the cruise the right side also looks toward the Rhine valley and southern Germany as the route tracks east-northeast. The Prague arrival on the left is good but brief; the London departure on the right is the highlight of the flight.

During takeoff from Heathrow (LHR), sit on the Right side for the best views. Heathrow typically departs eastbound on runways 09L/09R, so a right-side seat looks south over central London as the aircraft climbs and turns. You get a clear view of the Thames snaking through the city, with the Canary Wharf cluster and the City of London skyline visible before the aircraft heads northeast. Notable sights include: River Thames bends through central London, Canary Wharf tower cluster, The Shard and City of London skyline, Windsor Castle and Windsor Great Park (briefly visible to the south before the turn).

When landing at Ruzyne (PRG), sit on the Left side for the best views. Prague Ruzyne typically lands westbound on runway 06/24 or uses runway 24, meaning the aircraft approaches from the east and descends over the city. A left-side seat on approach from the east gives a view over Prague's historic center, with the Vltava River and Prague Castle clearly visible as the aircraft descends below 5,000 feet. Notable sights include: Vltava River curving through Prague city center, Prague Castle and Hradcany hill, Old Town and Charles Bridge area, Bohemian lowland farmland patchwork on approach.

The flight from Heathrow (LHR) to Ruzyne (PRG) takes Approximately 2 hours.

The route tracks east-northeast over the English Channel near Calais, then across Belgium and the flat lowlands of the Netherlands and western Germany. Over Germany the terrain rises gently toward the Bohemian Forest (Bayerischer Wald / Šumava) on the Czech border, visible as a dark forested ridge before descending into the Bohemian Basin toward Prague. No dramatic mountain ranges cross the route directly, but the Rhine valley may be visible to the south on clear days.