Sit on the Right side of the plane for the best views on flights from Orlando to Las Vegas. The Las Vegas arrival on the right side delivers the most dramatic and iconic single view of the flight — the Strip and Spring Mountains together. The Orlando departure on the left is interesting but Florida's flat terrain limits the spectacle. Right side wins overall for the Las Vegas approach alone.

During takeoff from Orlando International (MCO), sit on the Left side for the best views. MCO typically departs northwest on runway 18L/36R or uses runways oriented north-south. Climbing out westbound toward Las Vegas, the left (south) side gives you a clear view over the Orlando urban grid, the chain of lakes through the city, and Walt Disney World's distinctive layout visible as a large developed complex southwest of the airport. The right side faces north toward less distinctive suburban sprawl. Notable sights include: Walt Disney World resort complex (southwest), Lake Tohopekaliga and the Kissimmee chain of lakes (south), Orlando downtown skyline (northwest), Lake Conway system (west of airport).

When landing at Mc Carran International (LAS), sit on the Right side for the best views. Las Vegas McCarran typically receives westbound arrivals from the east, often using runways 26L/26R or 25L/25R, meaning the aircraft approaches from the east over the desert. The right (north) side gives you the Las Vegas Strip laid out clearly below and slightly ahead, with the Spring Mountains and Red Rock Canyon visible to the west beyond the city. The left side faces south toward Henderson and open Mojave desert. Notable sights include: Las Vegas Strip (north, clearly visible from approach), Spring Mountains and Charleston Peak to the west, Lake Mead reservoir to the northeast, Red Rock Canyon escarpment west of the city.

The flight from Orlando International (MCO) to Mc Carran International (LAS) takes Approximately 4 hours 15 minutes to 4 hours 45 minutes westbound.

The flight crosses the Gulf Coast of Florida briefly, then tracks over the Mississippi Delta region and Louisiana wetlands, crosses Texas hill country and the Permian Basin oil fields (visible pump jacks and tank farms), passes over New Mexico's high desert plateau and the Rio Grande valley near Albuquerque, then crosses Arizona's Colorado Plateau with the Grand Canyon visible to the north if routing allows, before descending into the Mojave Desert and Las Vegas valley. The transition from green Gulf Coast to brown Sonoran and Mojave desert is one of the most visually dramatic color shifts on any domestic US route.