Sit on the Left side of the plane for the best views on flights from Rio Negro to Miami. The left side delivers the dramatic Medellín valley and Andes departure, then tracks the Caribbean coastline of Colombia and Central America through the flight's middle portion, and still catches Biscayne Bay on approach. The right side has a strong Miami landing view but misses the more spectacular departure scenery.

During takeoff from Jose Maria Cordova (MDE), sit on the Left side for the best views. Jose Maria Cordova's primary runway 01/19 means northbound departures climb out heading roughly north, putting the Andes cordillera and the Medellín valley to the left (west). The left side gets a direct view down into the urban bowl of Medellín and the steep ridgelines of the Western Cordillera rising beyond it. Notable sights include: Medellín city center and El Centro district below, the Aburrá Valley urban corridor stretching north-south, the Western Cordillera ridgeline to the west, Cerro El Volador and surrounding barrios.

When landing at Miami International (MIA), sit on the Right side for the best views. MIA's primary arrival runways 08L/08R and 09 bring aircraft in from the east over the Atlantic, meaning the right side faces south toward the Florida Keys chain and Biscayne Bay during the approach. The left side looks north over suburban sprawl with less visual interest. Notable sights include: Biscayne Bay and its shallow turquoise waters, the Florida Keys chain extending southwest toward the horizon, the Miami Beach barrier island and Atlantic coastline, downtown Miami skyline to the north.

The flight from Jose Maria Cordova (MDE) to Miami International (MIA) takes Approximately 3 hours 30 minutes to 4 hours.

After leaving Colombia the route crosses the Caribbean Sea, passing north of the Guajira Peninsula and the Colombian coast. The flight then tracks over the western Caribbean, with the Yucatan Peninsula of Mexico potentially visible to the left at cruising altitude. Cuba's long narrow landmass crosses the flight path before the aircraft descends toward southern Florida over the Straits of Florida.