Sit on the Left side of the plane for the best views on flights from Mexico City to Boston. The left side wins overall because the Boston Harbor and skyline arrival is one of the most iconic urban approaches in the US, and the left side also captures the Gulf Coast and Atlantic seaboard during cruise. The right side's volcanic views at departure are spectacular but brief, while the left side delivers sustained interest across the Gulf of Mexico and the Eastern Seaboard.

During takeoff from Licenciado Benito Juarez International (MEX), sit on the Right side for the best views. Mexico City's main departure runway 05R sends the aircraft northeast, putting the right side facing northwest toward the Sierra Nevada volcanic chain. Popocatépetl and Iztaccíhuatl are clearly visible as snow-capped peaks rising above the Valley of Mexico, and the dense urban sprawl of CDMX fills the foreground before giving way to the basin rim. Notable sights include: Popocatépetl (active volcano, 17,802 ft), Iztaccíhuatl (dormant volcano, 17,159 ft), the urban grid of Mexico City spreading across the basin, Texcoco lakebed remnants to the northeast.

When landing at General Edward Lawrence Logan International (BOS), sit on the Left side for the best views. Logan Airport's primary northeast arrival (runway 33L/22R depending on winds) typically brings aircraft in over Massachusetts Bay from the south or southeast. The left side gets a direct view of Boston Harbor, the downtown skyline, and Cape Cod Bay in the distance. The right side faces inland toward suburban sprawl with far less visual interest. Notable sights include: Boston Harbor and its islands, downtown Boston skyline (Prudential Tower, Hancock Tower), Cape Cod peninsula visible to the south, the Charles River basin.

The flight from Licenciado Benito Juarez International (MEX) to General Edward Lawrence Logan International (BOS) takes Approximately 5 hours 15 minutes to 5 hours 45 minutes.

The route tracks northeast over the Gulf of Mexico, crossing the Yucatan Peninsula or the Gulf itself depending on routing, then over the Gulf Coast near Louisiana or Mississippi, up through the Appalachian Mountains of Tennessee, Virginia, and the mid-Atlantic states, before descending over New England. The Appalachian ridgelines are visible as parallel corrugated terrain from altitude, and on clear days the Chesapeake Bay and Delaware Bay are recognizable coastal inlets on the left side during descent.