Sit on the Left side of the plane for the best views on flights from Mexico City to Frankfurt. The left side wins at both ends of this flight. Departing Mexico City, the left window captures the volcanic Sierra Nevada peaks. Arriving into Frankfurt, the left side faces north over the Main River and city skyline. The transatlantic cruise at 35,000 feet over the Gulf of Mexico, Atlantic, and Europe offers limited differentiation between sides, but the bookend views both favor left.

During takeoff from Licenciado Benito Juarez International (MEX), sit on the Left side for the best views. MEX primarily uses runways 05R/23L and 05L/23R. Departing northeast on runway 05, the left side faces northwest toward the Sierra Nevada volcanic chain including Popocatépetl and Iztaccíhuatl. These two massive stratovolcanoes dominate the skyline southeast of the city, but on a northeastward departure the left window captures the snow-capped peaks as the aircraft climbs and banks. On the more common northeastward departure heading, the left side also captures the urban sprawl of Mexico City spreading across the Basin of Mexico. Notable sights include: Popocatépetl volcano (5,426m, active with visible fumaroles), Iztaccíhuatl volcano (5,230m, snow-capped ridge), the dense urban grid of Mexico City spreading across the Valley of Mexico, Lake Texcoco remnant wetlands to the northeast.

When landing at Frankfurt Main (FRA), sit on the Left side for the best views. Frankfurt airport sits south of the city and typically lands from the west on runways 07L/07R in eastward approaches, or from the east on 25L/25R. On the common westerly approach (runway 25), aircraft track eastward over the Rhine-Main region. The left side faces north, giving views over Frankfurt's city center, the Main River bends, and the distinctive Taunus hills. The right side faces south toward flat agricultural land with less visual interest. Notable sights include: Frankfurt city skyline (Bankenviertel skyscrapers visible as a cluster), the Main River curving through the urban area, the Taunus hill range to the north, Rhine River valley to the northwest.

The flight from Licenciado Benito Juarez International (MEX) to Frankfurt Main (FRA) takes Approximately 12 to 13 hours.

The route tracks northeast from Mexico City over the Gulf of Mexico, crossing the Atlantic roughly between the Azores archipelago (visible as small dark islands in deep blue ocean if routing passes nearby) and the Canary Islands latitude. Over the eastern Atlantic and into Europe, the flight crosses the Iberian Peninsula or Bay of Biscay depending on routing, then over France before descending into the Rhine-Main region. The Azores may appear as small volcanic island dots in the mid-Atlantic if the great circle route passes within 100 miles.