Sit on the Right side of the plane for the best views on flights from Miami to Santiago. The right side delivers the Atlantic coastline and Biscayne Bay on departure, then the Andes on approach into Santiago — the two most visually compelling moments of the flight. The left side has the Everglades and the Pacific on descent, which are comparatively featureless.

During takeoff from Miami International (MIA), sit on the Right side for the best views. MIA departures heading south typically use runways oriented east-west or north-south. On a southbound departure, the right side gives you Biscayne Bay, the Miami Beach barrier islands, and the Atlantic coastline as you climb out over South Florida. The left side faces inland toward the Everglades. Notable sights include: Biscayne Bay, Miami Beach and South Beach barrier island, Port of Miami on Dodge Island, Florida Keys chain beginning to the south.

When landing at Arturo Merino Benitez International (SCL), sit on the Right side for the best views. SCL approaches typically come in from the north or northwest, landing eastward toward the Andes. On the right side you get a direct broadside view of the Andes cordillera including Aconcagua and the high peaks forming the Chile-Argentina border, which is the most dramatic scenery of the entire flight. The left side faces north over the flat Central Valley. Notable sights include: Andes cordillera including Aconcagua (6,961m), Santiago urban basin in the Central Valley, Cajón del Maipo canyon mouth, snow-capped volcanic peaks along the border ridge.

The flight from Miami International (MIA) to Arturo Merino Benitez International (SCL) takes Approximately 8.5 to 9.5 hours.

The route tracks south over Cuba and the Caribbean Sea, then crosses Colombia and Ecuador near the Pacific coast, passes over Peru's coastal desert and the Atacama Desert in northern Chile — one of the driest and most barren landscapes on Earth visible as a pale tan expanse — before descending into Santiago's Central Valley with the Andes to the east.