Sit on the Left side of the plane for the best views on flights from Miami to St. Louis. While the right side wins at takeoff with Miami's coastal scenery, the left side delivers the more dramatic payoff at landing with the Mississippi River crossing and the Gateway Arch. During the cruise northwestward, the left side also tracks closer to the Gulf Coast and Tennessee River valley terrain, making it the better overall seat for the full flight.

During takeoff from Miami International (MIA), sit on the Right side for the best views. MIA typically departs east on runway 08R/09, then turns northwest toward STL. The right side gets a clear view over Biscayne Bay, the Miami Beach barrier island, and the Atlantic Ocean during the initial climb before the aircraft banks northwest. Downtown Miami's skyline is also visible to the right during the turn. Notable sights include: Biscayne Bay, Miami Beach barrier island, Port of Miami, Downtown Miami skyline.

When landing at Lambert St Louis International (STL), sit on the Left side for the best views. Lambert STL typically lands westbound on runway 30L/30R, meaning the aircraft approaches from the east over Illinois. The left side gives a direct view of the Mississippi River, the Gateway Arch, and downtown St. Louis as the plane descends over the Illinois flatlands before crossing the river. Notable sights include: Mississippi River, Gateway Arch, Downtown St. Louis skyline, Missouri River confluence.

The flight from Miami International (MIA) to Lambert St Louis International (STL) takes Approximately 2 hours 45 minutes to 3 hours.

The flight tracks northwest over central Florida, crossing Lake Okeechobee (one of the largest freshwater lakes in the US, clearly visible from altitude), then over the Florida Panhandle or southern Georgia and Alabama. The route crosses the Tennessee River valley and the low ridges of the southern Appalachian foothills in northern Alabama and Tennessee before flattening into the Mississippi embayment and Missouri farmland approaching St. Louis.