Sit on the Left side of the plane for the best views on flights from Myrtle Beach to St. Louis. While takeoff offers coastal scenery, the landing approach provides more dramatic and distinctive views of the Mississippi River and St. Louis's urban geography. The river's meanders and the city's relationship to the waterway are more visually compelling than the relatively flat coastal departure.

During takeoff from Myrtle Beach International (MYR), sit on the Right side for the best views. Right-side seats offer views of the Atlantic coastline and Myrtle Beach's barrier islands during the initial climb-out heading northwest. You'll see the contrast between the developed beach area and open ocean, plus the Grand Strand's distinctive linear geography. Notable sights include: Atlantic Ocean, Myrtle Beach developed coastline, Waccamaw River delta, barrier island chain.

When landing at Lambert St Louis International (STL), sit on the Left side for the best views. Left-side seats provide excellent views of the Mississippi River and St. Louis's urban core during descent. The river's distinctive meanders and the Gateway Arch area are clearly visible on approach from the east, and you'll see the river's relationship to the city's layout. Notable sights include: Mississippi River with meanders, Gateway Arch and downtown St. Louis, Illinois bluffs across the river, urban sprawl extending east.

The flight from Myrtle Beach International (MYR) to Lambert St Louis International (STL) takes Approximately 2 hours 45 minutes.

The flight path crosses inland South Carolina (Pee Dee River region), then enters North Carolina's Piedmont, crosses the Appalachian foothills, and transitions into Tennessee and Kentucky before reaching the Mississippi River valley. Notable midpoint features include the Appalachian Mountains' eastern ridges (visible as distant ridges around 20,000+ feet), the Tennessee River valley, and the transition from forested Appalachian terrain to the flatter Mississippi River basin.