Sit on the Left side of the plane for the best views on flights from Panama City to Boston. The left side wins overall because the Panama Canal departure view is genuinely spectacular and hard to beat, and through the Caribbean and along the US East Coast the left side tracks closer to land — giving views of Cuba, the Bahamas chain, and the Florida/Carolina coastlines in the middle portion of the flight.

During takeoff from Tocumen International (PTY), sit on the Left side for the best views. Tocumen typically departs northeast on runway 03L/03R, putting the left side facing northwest over Panama City and the Pacific entrance to the Panama Canal. You get a clear view of the Bridge of the Americas and the canal's Pacific locks before the aircraft turns north. Notable sights include: Panama Canal Pacific entrance and Miraflores Locks, Bridge of the Americas, Panama City skyline (Punta Pacifica towers), Pacific Ocean coastline.

When landing at General Edward Lawrence Logan International (BOS), sit on the Right side for the best views. Logan typically lands from the south or southwest on runways 04R/04L or 22L/22R depending on wind. On the common approach from the south over Massachusetts Bay, the right side gives you Boston Harbor, the downtown skyline, and Cape Cod in the distance. On a southwest approach, right side still captures the harbor and city center. Notable sights include: Boston Harbor and its islands, downtown Boston skyline (Financial District and Back Bay), Cape Cod peninsula visible to the southeast, Charles River and Cambridge.

The flight from Tocumen International (PTY) to General Edward Lawrence Logan International (BOS) takes Approximately 5 hours 30 minutes to 6 hours.

The flight tracks north-northwest over the Caribbean Sea, passing west of Jamaica and over western Cuba or the Yucatan Channel, then across the Gulf of Mexico or Florida Straits, up the US East Coast over Florida, the Carolinas, Virginia, and the Mid-Atlantic states before descending into Boston. The Bahamas archipelago is visible as shallow turquoise water and low sandy cays. Cuba's mountainous Sierra Maestra range appears in the east if routing takes you near the island. The Gulf Stream's distinctive deep blue color contrasts with shallower Bahamian waters. The Appalachian ridgelines are faintly visible as parallel dark green corrugations running northeast through the Carolinas and Virginia.