Sit on the Left side of the plane for the best views on flights from St. Louis to Charlotte. The left side delivers the most dramatic single moment of the flight — the Gateway Arch and St. Louis riverfront on departure — which outweighs the right side's Charlotte approach views. During cruise at altitude the flight tracks southeast across Kentucky and the western Appalachian foothills, where neither side has a decisive advantage, but the departure spectacle tips the balance to the left.

During takeoff from Lambert St Louis International (STL), sit on the Left side for the best views. Lambert typically departs eastbound on runway 12R/30L or uses runways oriented northeast-southwest. On an eastbound departure toward Charlotte, the left (north) side gives you a clear view back over downtown St. Louis, the Gateway Arch, and the Mississippi River as the aircraft banks southeast. The Arch and riverfront are unmistakable from this angle. Notable sights include: Gateway Arch and St. Louis riverfront, Mississippi River bends, downtown St. Louis skyline, Cahokia Mounds (Illinois side).

When landing at Charlotte Douglas International (CLT), sit on the Right side for the best views. Charlotte Douglas typically receives aircraft from the west or northwest, with final approach often on runway 18C/36C or 18L/36L oriented north-south. On approach from the west-northwest, the right (west/north) side gives views over the Charlotte skyline and uptown district as the aircraft descends. The left side faces south toward less distinctive suburban sprawl. Notable sights include: Charlotte uptown skyline, Lake Norman to the north, Lake Wylie to the southwest, Catawba River corridor.

The flight from Lambert St Louis International (STL) to Charlotte Douglas International (CLT) takes Approximately 1 hour 45 minutes to 2 hours.

The flight crosses southern Illinois farmland, the Ohio River near Evansville or Louisville, then tracks across western Kentucky and Tennessee. The Cumberland Plateau and the western ridges of the Appalachians become visible as the aircraft descends toward Charlotte, with the Blue Ridge escarpment visible on the horizon to the east. No major cities directly below at cruise altitude, but Nashville lies to the southwest and Knoxville to the southeast depending on routing.