Sit on the Right side of the plane for the best views on flights from Knoxville to Rome. While the takeoff offers good mountain views on the left, the landing approach on the right provides more dramatic and iconic scenery: the Apennine Mountains, the Tiber River valley, and Rome's urban landscape. The landing experience outweighs the takeoff.

During takeoff from Mc Ghee Tyson (TYS), sit on the Left side for the best views. Left seats offer views of the Great Smoky Mountains as the aircraft climbs northeast out of Knoxville. The ridgelines and valleys are distinctive and visible within the first 15–20 minutes of flight. Notable sights include: Great Smoky Mountains (south and southwest), Tennessee River valley (north), Knoxville urban area (directly below during initial climb).

When landing at Fiumicino (FCO), sit on the Right side for the best views. Right seats provide excellent views of the Apennine Mountains and the Roman Campagna (agricultural plain) during descent into Rome. The Tiber River valley and the city's urban sprawl become visible in the final approach phases. Notable sights include: Apennine Mountains (south and southeast), Tiber River valley (running north-south through the frame), Rome urban area and surrounding Campagna plain, Mediterranean coast (distant, visible on clear days).

The flight from Mc Ghee Tyson (TYS) to Fiumicino (FCO) takes 9h 15m.

The flight crosses the Atlantic over the North Atlantic Ocean, with the Mid-Atlantic Ridge and deep ocean basins forming the primary geography for roughly 6 hours of flight time. Upon approaching European airspace, the flight passes over the British Isles (if routed via northern corridor) or the Bay of Biscay and Iberian Peninsula (if routed via southern corridor). The Alps or Pyrenees may be visible depending on the specific routing. The final approach into Rome crosses the Italian peninsula, with the Apennine Mountains running north-south and the Tyrrhenian Sea visible to the west.