Sit on the Right side of the plane for the best views on flights from Rome to Knoxville. While the Rome departure offers interesting volcanic and river geography, the Knoxville landing provides more dramatic and visually distinctive mountain scenery. The Great Smoky Mountains during descent are more impressive than the relatively subtle Alban Hills near Rome.

During takeoff from Fiumicino (FCO), sit on the Left side for the best views. Left side offers views of the Tiber River valley and the Alban Hills (Castelli Romani) as the aircraft climbs southeastward from Fiumicino. Right side faces the Tyrrhenian Sea with less distinctive terrain during initial climb. Notable sights include: Tiber River winding through the Roman Campagna, Alban Hills volcanic ridge to the southeast, Mediterranean coastline receding westward, Pontine Marshes (Agro Pontino) to the south.

When landing at Mc Ghee Tyson (TYS), sit on the Right side for the best views. Right side provides views of the Great Smoky Mountains and the Tennessee Valley as the aircraft descends toward Knoxville from the northeast. The ridgelines and river valleys are visually striking during final approach. Notable sights include: Great Smoky Mountains (northern ridgelines), Tennessee River valley, Knoxville urban area in the valley floor, Clinch River confluence.

The flight from Fiumicino (FCO) to Mc Ghee Tyson (TYS) takes 9h 15m.

The flight path crosses the Atlantic Ocean for approximately 4,500 nautical miles. Notable geographic features along the route include: the Irish coast and Celtic Sea (if tracking northerly), the Mid-Atlantic ridge (underwater, not visible), Newfoundland and the Canadian Maritime provinces, the Appalachian Mountain chain as the aircraft approaches North America, and the Ohio River valley system before reaching the Tennessee region.