Sit on the Left side of the plane for the best views on flights from Knoxville to Las Vegas. The left side delivers the dramatic Appalachian departure views including the Smokies, then tracks along the southern edge of the route with views into the Colorado Plateau and Zion/Bryce Canyon area in Utah to the north during cruise. The right side wins on landing, but the left side has more sustained scenic value across the full flight.

During takeoff from Mc Ghee Tyson (TYS), sit on the Left side for the best views. TYS typically departs runway 23L heading southwest, then turns northwest toward the route. The left side captures the Great Smoky Mountains and the Tennessee River valley as you climb out. The ridge-and-valley Appalachian terrain is dramatically visible on the left during the initial climb. Notable sights include: Great Smoky Mountains (GSMNP ridgeline to the south), Tennessee River and Fort Loudoun Lake, Clinch Mountain ridge to the north, downtown Knoxville grid.

When landing at Mc Carran International (LAS), sit on the Right side for the best views. McCarran typically lands runway 26L or 19R depending on winds. On the common westward approach, the right side faces north and captures the Las Vegas Strip, Frenchman Mountain, and Lake Mead in the distance. The Strip is unmistakably visible on the right during final approach from the east. Notable sights include: Las Vegas Strip (visible as a dense cluster of towers), Lake Mead to the northeast, Frenchman Mountain (the red rocky ridge east of the city), Hoover Dam area.

The flight from Mc Ghee Tyson (TYS) to Mc Carran International (LAS) takes Approximately 3 hours 45 minutes to 4 hours.

The flight crosses the Mississippi River near Memphis, then the Arkansas and Oklahoma plains, the Texas Panhandle flatlands, the New Mexico high desert and Sangre de Cristo foothills to the north, the Colorado Plateau with canyon country visible in southern Utah, and the Mojave Desert on descent into Las Vegas. The transition from green eastern lowlands to arid red-rock plateau country is the most visually dramatic shift of the flight, occurring roughly over eastern New Mexico and Arizona.