Sit on the Right side of the plane for the best views on flights from Toronto to St. Louis. Right-side seats win overall because the takeoff views of Lake Ontario and Toronto's waterfront are more visually striking than the landing approach. While the Mississippi River and Gateway Arch on the left during landing are notable, the extended lake views during departure from YTZ offer more sustained scenic interest.

During takeoff from City Centre (YTZ), sit on the Right side for the best views. Right-side seats offer views of Lake Ontario immediately after departure from YTZ. The aircraft climbs southwestward over the lake before turning toward St. Louis, giving right-side passengers a clear view of Toronto's waterfront and the open water. Notable sights include: Lake Ontario, Toronto Islands, Scarborough Bluffs, Toronto downtown skyline.

When landing at Lambert St Louis International (STL), sit on the Left side for the best views. Left-side seats provide excellent views during the approach to STL. Aircraft descend from the northeast, and left-side passengers see the Mississippi River and its distinctive meanders, plus the St. Louis metropolitan area and the Gateway Arch before touchdown. Notable sights include: Mississippi River, Gateway Arch, St. Louis downtown, Illinois bluffs.

The flight from City Centre (YTZ) to Lambert St Louis International (STL) takes Approximately 2 hours 15 minutes.

The flight path crosses from Ontario southwestward over Michigan (Lake Michigan visible to the left/north during cruise), then over Indiana and Illinois. Notable midpoint features include Lake Michigan's eastern shoreline, the Indiana-Illinois border region, and the transition from the Great Lakes basin to the Mississippi River valley. The terrain gradually becomes flatter as the aircraft moves from the Great Lakes region toward the Mississippi River system.