Sit on the Right side of the plane for the best views on flights from Toronto to Cayo. While the left side wins at takeoff for the Toronto skyline and Lake Ontario, the right side delivers the more sustained and visually dramatic experience: it tracks the western shore of Lake Ontario as the flight heads south, then picks up views of the US eastern seaboard, and delivers the spectacular shallow-water Caribbean approach into Cayo Coco. The turquoise reef and cay scenery on arrival is the highlight of the whole flight.

During takeoff from Lester B Pearson International (YYZ), sit on the Left side for the best views. YYZ's most common departure is eastbound on runway 23/05 or southbound on 33/15. A southbound or southeast departure puts Lake Ontario directly on the left side, with the Toronto downtown skyline and CN Tower visible as the aircraft climbs out over the western lakeshore. The left side tracks the urban core and waterfront before the aircraft turns south. Notable sights include: CN Tower and downtown Toronto skyline, Lake Ontario shoreline, Toronto Islands, Hamilton Harbour to the southwest.

When landing at Vilo Acuna (CYO), sit on the Right side for the best views. Cayo Coco Airport (CYO) sits on a narrow coral island in the Jardines del Rey archipelago, and aircraft typically approach from the north over open water. A right-side seat on approach gives views of the turquoise shallow Bahía de Perros and the causeway connecting the cays to mainland Cuba, while the left side faces open ocean. Notable sights include: Cayo Coco and Cayo Guillermo coral cays, Bahía de Perros shallow turquoise bay, Pedraplén causeway connecting cays to mainland, Caribbean reef patterns in shallow water.

The flight from Lester B Pearson International (YYZ) to Vilo Acuna (CYO) takes Approximately 3 hours 30 minutes to 4 hours.

The flight tracks south over Lake Ontario's eastern basin, crosses into US airspace over western New York or Pennsylvania, then passes over the Appalachian ridges of West Virginia and Virginia visible as parallel forested ridgelines. The route continues over the Carolinas and Georgia before crossing the Florida Straits — a broad open-water crossing of roughly 90 miles — and entering Cuban airspace over the northern coast near Ciego de Ávila province, with the flat agricultural interior of Cuba visible before the final descent over the Jardines del Rey cays.